ea0073pep1.2 | Presented ePosters 1: Adrenal and Cardiovascular Endocrinology | ECE2021
Auchus Richard
, Merke Deborah
, Ivy-Joan Madu
, Nakhle Samer
, Sarafoglou Kyriakie
, Huang Michael
, Moriarty David
, Barnes Chris
, Newfield Ron
BackgroundCongenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is an autosomal recessive disorder characterized by insufficient cortisol production resulting in excess adrenocorticotropic hormone (ACTH) and adrenal androgen production. Standard-of-care therapy with glucocorticoids (GC) is suboptimal due to the difficulty of balancing control of the ACTH-driven androgen excess against the serious long-term side effects associated...